The interaction between genetics and lifestyle in promoting health and preventing diseases – Elina Sillanpää's research group

Our research group investigates interactions of genetic inheritance and lifestyle factors in developing common diseases, biological aging, and healthy life span. We utilize interdisciplinary approaches and the latest genetic and epidemiological methods in our studies. Our goal is to generate knowledge that can be utilized in promoting health and well-being, such as developing more personalized methods for disease prevention, treatment, and rehabilitation.
Group photo of the research team
Front row, from left: Kaisa Koivunen, Anni Pitkänen, Suvi Ravi, Elina Sillanpää, Katja Waller, Päivi Herranen, Tiina Föhr. Back row, from left: Annika Opperbeck, Elina Vettenterä, Anna Kankaanpää, Niko Tynkkynen, Laura Joensuu. Missing: Pia Pullinen

Table of contents

Research group type
Research group
Core fields of research
Physical activity, health and wellbeing
Research areas
JYU.Well
Physical activity through life span
Physical activity, wellbeing and behaviour change across the life-span
Molecular mechanisms of exercise and health
Active aging
Faculty
Faculty of Sport and Health Sciences

Research group description

We are interested in investigating and understanding genetic and lifestyle factors that predict biological aging, health, and functional capacity. We are committed to promoting health and well-being through an interdisciplinary approach and continuously strive to integrate the latest scientific findings and methods into our work.

In our research, we utilize advanced computational and quantitative genetic methods, biobank samples, health registries, and longitudinal twin cohort studies. Our research group's expertise in genetic epidemiology focuses on examining the relationship between genetic variants and diseases at the population level, and biobank studies enable the analysis of a wide range of associated data.

For instance, we define polygenic risk scores, which consist of numerous different gene variants and their interactions, to assess the risk of multifactorial traits and diseases. Additionally, we utilize epigenetic information, which reveals regulation of gene expression without changes in the DNA sequence. This information is valuable in our efforts to understand how environmental and lifestyle factors can influence gene function and thus health.

Through collaboration with health regions, we aim to bring research findings and methods closer to practical health and well-being work. This may include designing and evaluating health behavior interventions and developing health services. The results of our research can be utilized to better allocate resources and services according to the specific needs of the population and region, as well as to develop and implement more personalized methods in disease prevention, treatment, and rehabilitation.

Key datasets and collaborators

Twin research collaboration:

The Interplay of Genes and Environment across Multiple Studies (IGEMS) 

(Pedersen, N. L., Gatz, M., Finch, B. K., Finkel, D., Butler, D. A., Aslan, A. D., ... & Whitfield, K. E. (2019). IGEMS: the Consortium on interplay of genes and environment across multiple studies—an update. Twin Research and Human Genetics22(6), 809-816. doi:)

National and international biobanks and biobank studies:

 

The Trøndelag Health Study (

UK Biobank (

Finnish Biobank Cooperative&Բ;–  

National and international institutions and consortia:

Genetic and Biological factors that regulate Physical Activity Consortium (

Research group structure

The research group is led by Associate Professor in Health Promotion, Academy Research Fellow Elina Sillanpää. In addition to her, the research group currently consists of five postdoctoral researchers, six doctoral candidates, and one senior researcher. The research group also regularly includes master's students conducting their thesis work, as well as international visiting researchers and interns supported by programs such as JYU Visiting Fellow and ERASMUS funding.

JYU Visiting Fellows:

8/2024 PhD (University of Zaragoza)

4 /2023 Prof.(Norwegian School of Sport Sciences)

Research announcements and other highlights

Research group