The interaction between genetics and lifestyle in promoting health and preventing diseases – Elina Sillanpää's research group
Table of contents
Research group description
We are interested in investigating and understanding genetic and lifestyle factors that predict biological aging, health, and functional capacity. We are committed to promoting health and well-being through an interdisciplinary approach and continuously strive to integrate the latest scientific findings and methods into our work.
In our research, we utilize advanced computational and quantitative genetic methods, biobank samples, health registries, and longitudinal twin cohort studies. Our research group's expertise in genetic epidemiology focuses on examining the relationship between genetic variants and diseases at the population level, and biobank studies enable the analysis of a wide range of associated data.
For instance, we define polygenic risk scores, which consist of numerous different gene variants and their interactions, to assess the risk of multifactorial traits and diseases. Additionally, we utilize epigenetic information, which reveals regulation of gene expression without changes in the DNA sequence. This information is valuable in our efforts to understand how environmental and lifestyle factors can influence gene function and thus health.
Through collaboration with health regions, we aim to bring research findings and methods closer to practical health and well-being work. This may include designing and evaluating health behavior interventions and developing health services. The results of our research can be utilized to better allocate resources and services according to the specific needs of the population and region, as well as to develop and implement more personalized methods in disease prevention, treatment, and rehabilitation.
Key datasets and collaborators
Twin research collaboration:
The Interplay of Genes and Environment across Multiple Studies (IGEMS)
(Pedersen, N. L., Gatz, M., Finch, B. K., Finkel, D., Butler, D. A., Aslan, A. D., ... & Whitfield, K. E. (2019). IGEMS: the Consortium on interplay of genes and environment across multiple studies—an update. Twin Research and Human Genetics, 22(6), 809-816. doi:)
National and international biobanks and biobank studies:
The Trøndelag Health Study ()
UK Biobank ()
Finnish Biobank Cooperative&Բ;–
National and international institutions and consortia:
Genetic and Biological factors that regulate Physical Activity Consortium ()
Research group structure
The research group is led by Associate Professor in Health Promotion, Academy Research Fellow Elina Sillanpää. In addition to her, the research group currently consists of five postdoctoral researchers, six doctoral candidates, and one senior researcher. The research group also regularly includes master's students conducting their thesis work, as well as international visiting researchers and interns supported by programs such as JYU Visiting Fellow and ERASMUS funding.
JYU Visiting Fellows:
8/2024 PhD (University of Zaragoza)
4 /2023 Prof.(Norwegian School of Sport Sciences)