The role of nutrition in the prevention of common diseases

This study examines the role of diet during adolescence and adulthood in preventing common diseases. In younger adults who have not yet developed a disease, the disease risk is assessed by estimating biological aging with so-called epigenetic clocks. Epigenetic clocks have been developed to predict morbidity and the risk of premature death.

Table of contents

Project duration
-
Core fields of research
Physical activity, health and wellbeing
Research areas
JYU.Well
Physical activity, wellbeing and behaviour change across the life-span
Active aging
Molecular mechanisms of exercise and health
Co-operation
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Wellbeing Services County of Central Finland, Minerva Foundation Institute for Medical Research, University of Eastern Finland
Faculty
Faculty of Sport and Health Sciences
Funding
Juho Vainio Foundation

Project description

Non-communicable diseases, such as cardiovascular diseases, cancers, type 2 diabetes as well as Alzheimer's disease and other dementias, are diseases whose onset is influenced by both genetic and lifestyle factors. One of the most important modifiable lifestyle factors that is associated with a risk of mortality and morbidity is diet.

This research project examines whether healthy dietary habits can reduce the risk of disease also in individuals with a high genetic predisposition to a disease. In addition, this study aims to investigate if adolescent dietary habits are already associated with biological aging and subsequent disease risk. Finally, this study investigates if the strength of the link between dietary habits and disease risk is influenced by other lifestyle factors, such as physical activity and smoking.

The study utilizes genetically informed designs, such as twin models and computational genetics methods. The data used in the study are the Finnish twin cohort data and the data generated by biobank recall survey.

Project team

External members

Miina Ollikainen

Senior Researcher
Minerva Foundation Institute for Medical Research, Institute for Molecular Medicine Finland (FIMM)

Jaakko Kaprio

Professor
Institute for Molecular Medicine Finland (FIMM)

Leonie Bogl

Researcher
Bern University of Applied Sciences