MeRWi (Metabolic ReWiring of muscle cell glucose metabolism)
Do muscle cells behave like cancer cells, producing vital compounds in parallel pathways of glycolysis, and what is the role of this phenomenon in muscle size regulation?
Table of contents
Project duration
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Core fields of research
Physical activity, health and wellbeing
Research areas
Molecular mechanisms of exercise and health
Faculty
Faculty of Sport and Health Sciences
Funding
The Finnish Cultural Foundation
The Emil Aaltonen Foundation
Project description
The aim of our study is to find out whether muscle cells behave in a cancer cell-like manner, producing vital compounds in the glycolytic pathways and what role this phenomenon plays in muscle size regulation. In addition, we will investigate whether this metabolic reprogramming leads muscle cells to secrete different small molecule metabolites. We will use e.g., mouse muscle cells as well as muscle cells isolated from human muscle samples.
Project team
Project leaders
Project members
External members
Henning Wackerhage
Professor
TUM School of Medicine and Health, Munich
Philipp Baumert
Postdoctoral researcher
TUM School of Medicine and Health, Munich