Lynch syndrome, Lifestyle habits and Biomarkers -study

The research project investigates the links between lifestyle and various biomolecules measured in the bloodstream with cancer risk. The project focuses on individuals with an inherited cancer susceptibility syndrome called Lynch syndrome. Lynch syndrome increases the risk of several different types of cancer. It is caused by pathogenic forms in DNA repair genes.

Table of contents

Project duration
-
Core fields of research
Physical activity, health and wellbeing
Research areas
Physical activity through life span
JYU.Well
Faculty of Sport and Health Sciences - Research areas
Physical activity, wellbeing and behaviour change across the life-span
Molecular mechanisms of exercise and health
Active aging
Faculty
Faculty of Sport and Health Sciences
Funding
Horizon Europe
European Comission Marie Skłodowska-Curie Postdoctoral Fellowship (2022-2024), Mary and Georg C. Ehrnrooth Foundation (2023), Päivikki and Sakari Sohlberg Foundation (2021)

Project description

In the Lynch syndrome, lifestyle and biomarkers -study, the importance of lifestyle (physical activity and nutrition) and markers measured in blood is investigated from the point of view of the cancer risk of people with Lynch syndrome. The research material consists of, among other things, information collected using questionnaires and blood samples. Blood samples are analyzed for cell-free non-coding RNA and various metabolic products. Sequencing and nuclear magnetic resonance spectroscopy are used as measuring methods. The research is carried out in co-operation with several Finnish research centres and the Lynch syndrome registry.

The research has been funded by:
For cmiRCan subprojcet Mary and Georg C. Ehrnrooth Foundation (2023, PI Tiina Jokela) and
European Comission Marie Skłodowska-Curie Postdoctoral Fellowship for Tiina Jokela (2022-2024, host Eija Laakkonen)
For Cancelled Cancer subproject Päivikki and Sakari Sohlberg Foundation (2021, PI Eija Laakkonen)

Research documents (in Finnish)

Tutkimuksessa käytetyt kyselylomakkeet ja tutkimuksen tietosuojailmoitus

Project team

Project leaders

Eija Laakkonen

Eija Laakkonen

Associate professor
Tiina Jokela

Tiina Jokela

Research Director

Project members

Minta Kärkkäinen

Doctoral Researcher

Tia-Marje Korhonen

Postdoctoral Researcher

Henna Littunen

Research Assistant

External members

Toni Seppälä

apulaisprofessori, Tampereen yliopisto
Tampereen yliopisto, TAYS, Helsingin yliopisto, HUS

Jukka-Pekka Mecklin

tutkimusjohtaja, Jyväskylän yliopisto

Kirsi Pylvänäinen

tutkimusasiantuntija, Sairaala Nova

Research groups

Research group

Biogerontology and Translational Health Research – Eija Laakkonen's research group

menopause, estrogen,non-coding RNA-molecules, biomarkers, Lynch syndrome, cancer research

Related news

Tutkimusjohtaja Tiina Jokela
Science news
13.11.2024

Research Director Tiina Jokela from Biobank Central Finland and the Ä¢¹½Ö±²¥ prevents cancer by investigating lifestyles

Tiina Jokela’s responsibilities are divided between the Ä¢¹½Ö±²¥ and Biobank Central Finland. . Jokela’s responsibilities include the development of biobank activities and conducting research on cancer biomarkers.
Tero Sievänen
Dissertation news
17.9.2024

Cancer risk in Lynch syndrome can be assessed from circulating microRNA

In his doctoral dissertation completed at the Ä¢¹½Ö±²¥, Finland, Tero Sievänen demonstrates that the cancer risk of Lynch syndrome carriers can be assessed based on circulating microRNA profiles.