3.11.2021 The disconnected brain in major depression (Liu)
"Previous studies have suggested that major depression is associated with the abnormal connectivity between some brain regions, thus impacting patients' attention, memory, and emotional regulation. However, there is not a unifying theory of the pathophysiological mechanisms, and we need to develop advanced methods to reveal the dysconnectivity networks of major depression", says Wenya Liu, the author of this dissertation.
Wenya Liu's dissertation investigates the abnormal brain networks modulated by specific neural oscillations in major depression using a novel experimental paradigm, listening to music. In her work, a novel model based on coupled tensor decomposition is also proposed better to extract meaningful information from the collected electroencephalography data. This model can also be easily extended to other psychiatric disorders.
A series of brain networks are reported to be functionally disconnected compared with healthy subjects during music listening conditions and resting states. The neural oscillations that regulate those brain networks are also identified. Wenya Liu's research has provided potential biomarkers for the clinical diagnosis and treatment of major depression.
M.Eng. Wenya Liun ohjelmisto- ja tietoliikennetekniikan väitöskirjan "Dysconnectivity of Oscillatory Networks in Major Depression Disorder" tarkastustilaisuus on keskiviikkona 3.11.2021 klo 12 alkaen. Vastaväittäjänä Professori Fabio Babiloni (University of Rome Sapienza, Italia) ja kustoksena professori Timo Hämäläinen (Jyväskylän yliopisto). Väitöstilaisuuden kieli on englanti.
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